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Derek's AnswerView 2 Other Answers
Derek CollisonDerek Collison, Founder and CEO, Apcera
15 upvotes by Ronaldo Pagani Yamashita, Quora User, Harinderpal (Hans) Hanspal, (more)
AMQP, and implementations like RabbitMQ, are enterprise messaging systems built with things like durability, transactions, and formal queues. NATS was designed and built to be like a dial-tone publish-subscribe service, something that is always on and available. However, NATS does not provide durability or transactions, and its queuing model is interest-based only. It also protects itself, the NATS service, at all costs, so that it can always be available. This forms a great base platform for building scalable and reliable distributed systems, but is probably not a good fit for the typical enterprise application.