Based on a random sample of one person (myself, this morning, after our kettle gave up), water boiled in the microwave is very different if used to make coffee. The coffee granules act differently and a fine froth forms on the surface. It also tastes rather bad if you're used to kettle water. Scientifically there may be little different (although I suspect there is a very big difference because of the molecular activity profile), but experientially it's chalk and cheese.