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(Continue Reading)MAOIs in tobacco
The tobacco MAOIs harman and norharman are believed to be the potentiators that contribute most or all of the dependence potential for nicotine subsequent to smoking. These compounds, and possibly additional potentiators and synergens such as the pyrolytic aldehydes, other alkaloids present, and nicotine boosters such as ammonia, are required to produce nicotine dependence. It is impossible to demonstrate nicotine dependence clinically, when using pure nicotine and never-smokers, since it requires a tobacco vehicle to initiate dependence; the tobacco - and especially tobacc...