An ad network needs an ad serving platform to provide ad tags to publishers, manage creatives and campaigns from advertisers, track revenue, delivery, and ROI, and choose the optimal ad for every impression. Ad servers must be extremely reliable and deliver ads quickly in every region in which the network operates. Support for mobile, display, video, and native formats is key, as is integration with all major SSPs, ad exchanges, bidders, and data providers.
Some networks build their own technology, but most work with a partner due to the cost and complexity of keeping up with an ever-changing industry. The best ad servers for networks have extensive APIs that allow for customization and differentiation as well as powerful predictive optimization capabilities.
With hundreds of ad network clients, AppNexus is the most common ad server for ad networks. Right Media, owned by Yahoo, is probably #2. Some networks modify publisher ad servers like OpenX or DFP, but this has serious limitations in working with exchanges.